Aminopyridines and their use as anticonvulsants and sodium...

Details Aminopyridines and their use as anticonvulsants and sodium... Aminopyridines and their use as anticonvulsants and sodium...

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2403991

This invention relates to aminopyridines of Formula (I), or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1-R8, X and m are set in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Cette invention concerne des aminopyridines représentées par la formule (I), ou bien un sel pahrmaceutiquement acceptable, une prodrogue ou un solvat de des amimopyridines. Dans cette formule R¿1?-R¿8?, X et m sont comme définis dans les spécifications. L'invention concerne également l'utilisation de composés de formule (I) pour le traitement de dégâts neuronaux provoqués par une ischémie globale ou focale, pour le traitement ou la prévention de maladies neurodégénératives telles que la sclérose latérale amyotrophique, et pour le traitement, la prévention ou le soulagement de la douleur tant aiguë que chronique, et pour le traitement ou la prévention de la neuropathie diabétique. Ces composés sont notamment des agents anti-acouphènes, des anticonvulsants, des anti-maniaco-dépresseurs, des anesthésiques locaux et des antiarythmiques.

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