Aminopyrimidine derivatives and their medical use

Details Aminopyrimidine derivatives and their medical use Aminopyrimidine derivatives and their medical use

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/506 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/14 (2006.01) C07D 409/04 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2521340

A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables haue the meanings as defined in the specification. Further disclosed are a method of inhibiting IKK activity using a compound of formula I, a method of inhibiting production of TNF using a compound of formula I, a compound of formula I for use as a pharmaceutical, a pharmaceutical composition comprising a compound of formula I, and use of a compound of formula I in the manufacture of a medicament for use as an immunosuppressant or anti-inflammatory agent.

Cette invention a trait à un composé correspondant à la formule (I) ou à son sel, son ester, acceptables du point de vue pharmaceutique ou à son promédicament. Dans cette formule, les variables sont telles que définies dans le descriptif. L'invention concerne également une méthode permettant d'inhiber l'activité d'IKK grâce à l'utilisation d'un composé correspondant à la formule (I), une méthode permettant d'inhiber la production de facteur de nécrose des tumeurs grâce à l'utilisation d'un composé correspondant à la formule (I) comme pharmaceutique, une composition pharmaceutique contenant ledit composé ainsi que l'utilisation de celui-ci pour la préparation d'un médicament utilisable comme immunosuppresseur ou comme agent anti-inflammatoire.

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