Aminopyrimidines and pyridines

Details Aminopyrimidines and pyridines Aminopyrimidines and pyridines

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2465711

The present invention relates to aminopyrimidine and aminopyridine derivatives having the formula (I), wherein V, X, Y, Z, R1, R4, A, B and U have the value given in the specification. The compounds are useful as an inhibitor of IkB kinases and, therefore, may be used for the treatment of inflammatory, metabolic or malignant conditions.

L'invention concerne des dérivés d'aminopyrimidine et d'aminopyridine représentés par la formule (I). Les symboles V, X, Y, Z, R?1¿, R?4¿, A, B et U de ladite formule prennent les valeurs indiquées dans la description. Les composés considérés sont utiles comme inhibiteurs d'enzymes IkB kinase. On peut donc les employer pour le traitement des affections inflammatoires, métaboliques ou malignes.

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