C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2611470
The invention is directed to aminopyrimidine compounds of Formula I: where R3, B, Z, Q, p, q and R1 are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c- kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB . The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
L~invention se rapporte à des composés d~aminopyrimidine représentés par la formule (1) selon laquelle R3, B, Z, Q, p, q et R1 sont tels que définis dans la description, de tels composés sont utilisés en tant que modulateurs de protéine tyrosine kinase, en particulier en tant qu~inhibiteurs de FLT3 et/ou c-kit et/ou TrkB, de tels composés sont utilisés pour réduire ou inhiber l~activité kinase de FLT3 et/ou c-kit et/ou TrkB dans une cellule ou chez un sujet et de tels composés sont utilisés pour prévenir ou traiter chez un sujet un trouble prolifératif de cellules et/ou des troubles liés à la FLT3 et/ou c-kit et/ou TrkB. La présente invention concerne en outre des compositions pharmaceutiques comprenant des composés de la présente invention et des procédés destinés à traiter des conditions telles que des cancers et d~autres troubles prolifératifs de cellules.
Baumann Christian Andrew
Gaul Michael David
Xu Guozhang
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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