C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2611495
Abstract The invention is directed to aminopyrimidine compounds of Formula I: where R3, B, Z, r and R1 are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c- kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB . The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
La présente invention concerne des composés d'aminopyrimidines de formule I : où R3, B, Z, r et R1 sont tels que définis ici. L~invention décrit l~utilisation de tels composés comme modulateurs de la protéine tyrosine kinase, spécialement des inhibiteurs de FLT3 et/ou de c-kit et/ou de TrkB, l~utilisation de tels composés pour réduire ou inhiber l~activité de la kinase de FLT3 et/ou de c-kit et/ou de TrkB dans une cellule ou un sujet, ainsi que l~utilisation de tels composés pour empêcher ou traiter chez un sujet un trouble de prolifération cellulaire et/ou des troubles reliés à FLT3 et/ou à c-kit et/ou à TrkB. La présente invention vise en outre des compositions pharmaceutiques qui comprennent les composés de la présente invention et des procédés pour traiter des troubles tels que des cancers et autres troubles de prolifération cellulaire.
Baumann Christian Andrew
Gaul Michael David
Xu Guozhang
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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