Aminopyrimidines useful as kinase inhibitors

Details Aminopyrimidines useful as kinase inhibitors Aminopyrimidines useful as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2694381

The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compo-sitions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is A,B,C,D,E wherein said Ht is optionally and independently substituted with R2 and R2', provided that Ht is not pyrazolyl or thiazolyl; X is CH, N, 0, or S; Y is CH, N, 0, or S; Q is -O-, -NR'-, -S-, -C(=O)-, or -C(R')2-; R x is H or F; R y is -Z-R10; R1 is T- (Ring D);

L'invention concerne des composés servant d'inhibiteurs de protéines kinases Aurora. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant de tels composés et des procédés d'utilisation de ces composés, ainsi que des compositions servant à traiter des maladies, des troubles et des états pathologiques variés. L'invention concerne encore des procédés destinés à préparer les composés de l'invention. Les composés de l'invention sont représentés par la formule (I). L'invention concerne également un sel pharmaceutiquement acceptable de tels composés. Dans cette formule, Ht désigne A,B,C,D,E; Ht étant éventuellement indépendamment substitué par R2 et R2', à condition que Ht ne soit pas pyrazolyle ou thiazolyle; X désigne CH, N, 0, ou S; Y désigne CH, N, 0, ou S; Q désigne -O-, -NR'-, -S-, -C(=O)-, ou -C(R' )2-; Rx désigne H ou F; R? désigne -Z-R10; et R1 désigne T- (anneau D).

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