Aminopyrones and their use as atm inhibitors

Details Aminopyrones and their use as atm inhibitors Aminopyrones and their use as atm inhibitors

C - Chemistry, Metallurgy

07

D

C07D 409/04 (2006.01) A61K 31/395 (2006.01) A61K 31/5415 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2534300

Compounds of formula (I) wherein R1 and R2 together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring, X is S, NR~~ or CH2, R and R~ are hydrogen or specified substituents, and R~~ is a specified substituent, are useful as inhibitors of the kinase ATM (ataxia-telangiectasia mutated), particularly in the treatment of cancer and retroviral mediated diseases.

L'invention concerne les composés représentés par la formule (I). Dans cette formule R?1¿ et R?2¿ forment ensemble, avec un atome d'azote auquel ils sont rattachés, un noyau hétérocyclique éventuellement substitué, X représente S, NR'' ou CH¿2?, R et R' représentent un hydrogène ou des substituants spécifiques, et R'' représente un substituant spécifique. Ces composés sont utiles en tant qu'inhibiteurs de l'ATM (ataxia-telangiectasia mutée) kinase notamment dans le traitement de cancers et de maladies induites par des rétrovirus.

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