Aminopyrrolidines as chemokine receptor antagonists

Details Aminopyrrolidines as chemokine receptor antagonists Aminopyrrolidines as chemokine receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/438 (2006.01) A61K 31/517 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2669917

The present invention is directed to novel aminopyrrolidines of formula (I), pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Cette invention concerne des nouveaux aminopyrrolidines représentés par la formule I, des sels pharmaceutiquement acceptables de ceux-ci, des métabolites de ceux-ci, des isomères de ceux-ci, des stéréoisomères de ceux-ci ou des pro-médicaments de ceux-ci. Les variables étant telles que définies dans la description. Les composés représentés par la formule (I) sont utilisés en tant qu'antagonistes du récepteur de la chimiokine et, de ce fait, ils sont particulièrement utiles pour traiter certaines affections et maladies, plus spécialement, des affections et des maladies inflammatoires et des affections et des troubles proliférants, par exemple, des cancers.

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