Aminoquinoline derivatives

Details Aminoquinoline derivatives Aminoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/46 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) C07D 215/42 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2133620

Abstract The invention is concerned with aminoquinoline derivatives of the general formula Image I wherein the symbols R1 to R6 signify hydrogen or one or two thereof signifies (signify) alkyl and the others signify hydrogen, R7 and R8 signify alkyl, alkenyl or aralkyl or together with the N atom signify pyrrolidine or piperidine, optionally substituted by alkyl, octahydroindole or 3- azabicyclo[3,2,2]nonane and n = 0 or 1 or wherein the symbols R1 and R3 signify tri- or tetramethyl- ene, all remaining symbols to R6 signify hydrogen, n = 0 and R7 and R8 have the above significances or wherein the symbols R1 and R7 signify methylene or dimethylene and n = 1, R1 and R7 signify di- or trimethylene and n = 0, R3 and R7 signify di or trimethylene and n = 1 R3 and R7 signify tri- or tetramethylene and n = 0 R5 and R7 signify tri- or tetramethylene and n = 1 R1 and R5 signify di- or tri-methylene and n = 1, all remaining substituents signify hydrogen, except R8 which signifies alkyl, alkenyl or alkynyl or wherein the symbols R3 and R5 signify tri- or tetra- methylene and n = 1, all remaining substituents to R6 signify hydrogen and R7 and R8 signify alkyl, alkenyl or aralkyl or together with the N atom signify pyrrolidine or piperidine, optionally substituted by alkyl, R9 signifies hydrogen or halogen and R10 signifies halogen or trifluoromethyl, as well as pharmaceutically acceptable salts of basic compounds of general formula I for the manufacture of medicaments for the control of not only chloroquine-resistant malaria pathogens, but also of chloroquine-sensitive malaria pathogens.

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