Aminostilbazole derivative and medicine

Details Aminostilbazole derivative and medicine Aminostilbazole derivative and medicine

C - Chemistry, Metallurgy

07

D

C07D 213/36 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 213/42 (2006.01) C07D 213/60 (2006.01) C07D 213/76 (2006.01) C07D 213/89 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 405/06 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2187214

._.. - ABSTRACT The invention relates to an aminostilbazole derivative of the following formula or a hydrate thereof, and a salt thereof. Image wherein R1 and R2 each represents hydrogen etc.; R3, R4, R13, and R14 each represents hydrogen, C1-3 acyl, halogen, hydroxy etc.; R5 represents hydrogen or hydroxy-substituted C1-3 alkyl etc.; R6 represents benzenesulfonyl substituted by C1-3 alkoxy etc.; ring Y represents phenyl etc.; ring Z represents 4-pyridyl, its oxide etc. The compound is useful for the treatment of various malignant tumors.

Dérivé d'aminostilbazole représenté par la formule générale (I) ou hydrate et sel de ce dérivé, utile pour le traitement de divers types de tumeurs malignes. Dans cette formule, R<1> et R<2> représentent l'un et l'autre l'hydrogène, etc.; R<3>, R<4>, R<13> et R<14> représentent chacun l'hydrogène, un acyle C1-C3, un halogène, un hydroxy, etc.; R<5> représente l'hydrogène, un alkyle C1-C3 hydroxylé, etc.; R<6> représente un benzènesulfonyle à substitution C1-C3 alcoxy, etc.; la liaison Y représente le phényle, etc.; et la liaison Z représente un 4-pyridyle, un oxyde de cette substance, etc.

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