Aminostyryl ketones

Details Aminostyryl ketones Aminostyryl ketones

C - Chemistry, Metallurgy

07

C

167/179, 260/278

C07C 225/16 (2006.01) A61K 31/135 (2006.01) C07C 45/74 (2006.01) C07C 49/217 (2006.01) C07D 295/10 (2006.01) C07D 295/104 (2006.01)

Patent

CA 1339743

The present invention provides a compound of formula (I) (see fig. I) and the pharmaceutically acceptable acid addition salts thereof wherein R is a radical of formula R2-ALK-CO-CH=CH-, R1 and R2, which are the same or different, are selected from the group of radicals consisting of (see fig. II) (see fig. III) (see fig. IV) (see fig. V), (see fig. VI), and (see fig. VII) wherein R3 and R4, which are the same or different, are selected from the group consisting of -H, -CH3, -C2H5, -C3H7, -C4H9, phenyl-CH-2- and phenyl-(CH2)2- and R5 is selected from the group of radicals consisting of -CH3, phenyl, phenyl-CH2- and phenyl-(CH2)2- and alk and ALK, which are the same or different, are selected from the group of radicals consisting of -CH2-, -CH2-CH2-, (see fig. VIII), (see fig. IX), (see fig. X). The compounds have activity against certain animal tumours as well as human tumours.

592378

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