Aminosugar compound and process for production thereof

Details Aminosugar compound and process for production thereof Aminosugar compound and process for production thereof

C - Chemistry, Metallurgy

12

P

C12P 19/04 (2006.01) A61K 31/715 (2006.01) A61K 35/74 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C08B 37/00 (2006.01) C12N 1/20 (2006.01) A61K 31/7034 (2006.01) C07H 15/203 (2006.01)

Patent

CA 2721051

[Object] Disclosed is a compound useful as an active ingredient for a pharmaceutical composition having an .alpha.-amylase inhibitory activity, particularly a pharmaceutical composition for the treatment of diabetes. [Solution] An investigation has been made on a compound having an .alpha.- amylase inhibitory activity among the compounds produced by Streptomyces sp. strain 6982, which is a actinomycetes belonging to the genus Streptomyces, and it was confirmed that an aminosugar compound has an .alpha.-amylase inhibitory activity, thus completing the invention. The aminosugar compound of the present invention has an .alpha.-amylase-inhibitory activity, and therefore can be used as a prophylactic or therapeutic agent for diabetes, obesity, NASH (non--alcoholic steatohepatitis), particularly as an ameliorating agent for postprandial blood glucose elevation.

Cette invention concerne un composé utile à titre de principe actif pour une composition pharmaceutique ayant une activité d'inhibition de l'a-amylase, en particulier, une composition pharmaceutique pour le traitement du diabète. Des études ont été menées pour découvrir un composé ayant une activité d'inhibition de l'a-amylase parmi les composés produits par la souche 6982 de Streptomyces sp. qui est un actinomyces appartenant au genre Streptomyces, et il a été confirmé qu'un composé aminosucre possède une activité d'inhibition de l'a-amylase. Ledit composé aminosucre a une activité d'inhibition de l'a-amylase et peut, par conséquent, être utilisé à titre d'agent prophylactique ou thérapeutique pour le diabète, l'obésité, NASH (stéatohépatite non alcoolique), en particulier, à titre d'agent d'amélioration de l'élévation du glucose sanguin postprandial.

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