Aminotetrahydroindazoloacetic acids

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 37/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2728311

The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1 -R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

L'invention porte sur les composés représentés par la formule I : et sur des sels et esters pharmaceutiquement acceptables correspondants, dans laquelle formule Q, R1-R3 et n sont tels que définis dans la description détaillée et les revendications. De plus, la présente invention porte sur des procédés de fabrication et d'utilisation des composés représentés par la formule I, ainsi que sur des compositions pharmaceutiques contenant de tels composés. Les composés représentés par la formule I sont des antagonistes du récepteur CRTH2 et peuvent être utiles dans le traitement de maladies et de troubles associés à ce récepteur, tels que l'asthme.

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