C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/209, 260/239
C07D 223/16 (2006.01) C07C 45/00 (2006.01) C07C 45/51 (2006.01) C07C 49/755 (2006.01) C07C 57/58 (2006.01) C07C 59/64 (2006.01) C07C 205/56 (2006.01) C07D 243/04 (2006.01) C07D 243/10 (2006.01) C07D 491/056 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1241326
ABSTRACT OF THE DISCLOSURE This invention relates to compounds of general formula I Image (I) wherein A represents a -CH2-CH2-, -CH=CH-, -?H-CO- or -?H2-CO- group and B represents a methylene, carbonyl or thiocarbonyl group, or A represents a -CO-CO- or Image group and B represents a methylene group wherein the mark x signifies that the carbon or nitrogen atom so marked is bonded to the phenyl nucleus; E represents a straight-chained alkylene group containing 2 to 4 carbon atoms optionally substituted by an alkyl group con- taining 1 to 3 carbon atoms, or represents a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene group; R1 represents a hydrogen, fluorine, chlorine or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, alkylthio, hydroxy, alkoxy or phenylalkoxy group (in which each alkyl moiety may contain 1 to 3 carbon atoms) and R2 represents a hydrogen, chlorine or bromine atom or a hydroxy, alkoxy, phenylalkoxy or alkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms) or R1 and R2 together represent an alkylenedioxy group con- R3 and R4, which may be the same or different, each represents a hydrogen, fluorine, chlorine or bromine atom or an alkyl, hydroxy, alkoxy, nitro, amino, alkylamino or dialkylamino group, or R3 and R4 together represent a methylenedioxy group (in which each alkyl moiety may contain 1 to 3 carbon atoms); and R5 represents a hydrogen atom, an alkenyl group containing 3 to 5 carbon atoms or an alkyl or phenylalkyl group (in which the alkyl moiety in each case may contain 1 to 3 carbon atoms) and acid addition salts thereof which have valuable pharmacological properties, particularly the effect of lowering heart rate. The new compounds may be prepared using methods known per se.
481658
Austel Volkhard
Hauel Norbert
Heider Joachim
Kobinger Walter
Lillie Christian
Fetherstonhaugh & Co.
Thomae (dr. Karl) Gesellschaft Mit Beschrankter Haftung
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