C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2640924
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
La présente invention concerne de nouveaux aminotétrahydropyrannes substitués de formule structurale I qui sont des inhibiteurs de l'enzyme dipeptidylpeptidase-IV et qui peuvent être employés dans le traitement prophylactique ou thérapeutique de maladies dans lesquels l'enzyme dipeptidylpeptidase-IV est impliquée, comme le diabète, et particulièrement le diabète de type 2. La présente invention concerne également des compositions pharmaceutiques comprenant lesdits composés, ainsi que l'emploi desdits composés et compositions dans le traitement prephylactique ou thérapeutique de maladies dans lesquelles l'enzyme dipeptidylpeptidase-IV est impliquée.
Biftu Tesfaye
Caldwell Charles G.
Chen Ping
Cox Jason M.
Feng Danqing
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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