Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors...

Details Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors... Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/155 (2006.01) A61K 31/437 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2652367

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

La présente invention concerne de nouveaux aminotétrahydropyranes substitués de formule structurelle I qui sont des inhibiteurs de l'enzyme dipeptidyl peptidase-IV et qui sont utiles pour le traitement ou la prévention de troubles dans lesquels l'enzyme dipeptidyl peptidase-IV est impliquée, tels que le diabète et en particulier le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions pour prévenir ou traiter des maladies dans lesquelles l'enzyme dipeptidyl peptidase-IV est impliquée.

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