Aminotetralin derivatives and compositions and method of use...

C - Chemistry – Metallurgy – 07 – C

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C07C 217/74 (2006.01) A61K 31/13 (2006.01) C07C 323/38 (2006.01)

Patent

CA 2243243

The invention relates to aminotetralin derivatives of formula (I) wherein: R1 is methyl or ethyl; R2 is hydrogen, halogen, lower-alkoxy or thiolower-alkyl; R3 is hydrogen, halogen, lower-alkoxy or lower-alkyl; and the chiral center * is in the (S)(-) form; or a pharmaceutically acceptable acid-addition salt thereof, with the proviso that when R2 and R3 are both hydrogen, R1 must be methyl; to pharmaceutical compositions containing them and to methods for the treatment or prevention of movement disorders utilizing them.

L'invention concerne des dérivés de l'aminotétraline de la formule (I). Dans cette formule, R?1¿ est un méthyle ou un éthyle; R?2¿ est un hydrogène, halogène, alcoxy inférieur ou thioalkyle inférieur; R?3¿ est un hydrogène, halogène, alcoxy inférieur ou alkyle inférieur; et le centre chiral * a la forme (S)(-). L'invention concerne, également, un sel d'addition obtenu avec un acide acceptable sur le plan pharmaceutique. Une condition à satisfaire est que, quand R?2¿ et R?3¿ sont tous deux des hydrogènes, R?1¿ doit être un méthyle. L'invention concerne également des compositions pharmaceutiques contenant ces dérivés et des méthodes de traitement ou de prévention de troubles moteurs faisant appel à eux.

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