Aminotetralin derivatives as muscarinic receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 211/58 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 13/10 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 405/06 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2469055

This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, processes for their preparation and their use as therapeutic agents.

L'invention concerne des composés qui sont généralement des antagonistes des récepteurs muscariniques M2/M3 et qui sont représentés par la formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ sont définis dans la description, ou des isomères individuels, des mélanges racémiques ou non racémiques d'isomères, ou leurs sels ou solvates acceptables. L'invention concerne aussi des compositions pharmaceutiques contenant ces composés, des procédés de leur préparation et de leur utilisation en tant qu'agents thérapeutiques.

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