C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/26 (2006.01) C07C 275/32 (2006.01) C07C 335/14 (2006.01) C07D 213/36 (2006.01) C07D 213/40 (2006.01) C07D 215/38 (2006.01) C07D 217/02 (2006.01) C07D 217/08 (2006.01) C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 233/54 (2006.01) C07D 237/28 (2006.01) C07D 239/74 (2006.01) C07D 307/52 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01) C07D 333/32 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2486092
This invention is directed to vanilloid receptor VR1 ligands of formula (1). More particularly, this invention relates to .beta.-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
Cette invention porte sur des ligands du récepteur vanilloïde VR1 de formule (1), et notamment sur des urées dérivées de .beta.-aminotétraline qui sont de puissants antagonistes ou agonistes de VR1 et qui sont utiles dans le traitement et la prévention d'états inflammatoires et autres états douloureux chez des mammifères.
Codd Ellen
Dax Scott L.
Jetter Michele
Mcdonnell Mark
Mcnally James J.
Janssen Pharmaceutica N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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