Aminotetrazole derivatives useful as nitric oxide synthase...

Details Aminotetrazole derivatives useful as nitric oxide synthase... Aminotetrazole derivatives useful as nitric oxide synthase...

C - Chemistry, Metallurgy

07

D

C07D 257/06 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4168 (2006.01) A61K 31/4196 (2006.01) A61K 31/426 (2006.01) A61K 31/505 (2006.01) C07D 231/40 (2006.01) C07D 233/88 (2006.01) C07D 239/42 (2006.01) C07D 249/14 (2006.01) C07D 277/46 (2006.01)

Patent

CA 2203237

Compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein B is NR5R11, wherein R5 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl and aryl, and R11 is selected from a 3 to 8 member heterocyclyl radical in which at least one member of the ring is carbon and in which 1 to about 4 members are heteroatoms independently selected from oxygen, nitrogen and sulfur and said heterocyclyl radical may be optionally substituted, useful as nitric oxide synthase inhibitors.

Composés de formule (I) et sels pharmaceutiquement acceptables desdits composés, dans laquelle B est NR<5>R<11>, R<5> étant sélectionné dans le groupe constitué par hydrogène, alkyle inférieur, alcényle inférieur, alcynyle inférieur et aryle et R<11> étant un radical hétérocyclique de 3 à 8 éléments dans lequel au moins un élément du cycle est carbone et dans lequel 1 à 4 éléments sont des hétéroatomes choisis indépendamment parmi oxygène, azote et soufre, le radical hétérocyclique pouvant être éventuellement substitué, ces composés étant utiles en tant qu'inhibiteurs de la monoxyde d'azote synthétase.

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