Amlodipine free base

Details Amlodipine free base Amlodipine free base

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01) A61K 9/20 (2006.01) A61K 31/44 (2006.01) A61K 31/4422 (2006.01) A61K 47/36 (2006.01) A61K 47/38 (2006.01) A61P 9/12 (2006.01) C07D 209/48 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2433366

Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.

L'invention permet de créer des formulations de base libre d'amlodipine, sous forme de doses orales et notamment de comprimés, en évitant à ces comprimés une trop grande adhésivité ou l'apparition de résidus de poinçonnage trop importants. La base libre d'amlodipine peut être sous une forme I cristalline ou sous une nouvelle forme II. L'invention concerne en outre des procédés de fabrication et d'utilisation de la base libre d'amlodipine.

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