C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/90 (2006.01)
Patent
CA 2549832
The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.
L'invention concerne un sel acide de gentisate d'amlodipine et un procédé de fabrication de celui-ci. L'invention concerne plus particulièrement un sel acide cristallin de gentisate d'amlodipine représenté par la formule (I), fabriqué par réaction d'amlodipine et d'acide gentisique. Ledit sel acide cristallin de gentisate d'amlodipine sert au traitement de maladies cardiovasculaires et présente une faible toxicité, une excellente stabilité, de meilleurs effets pharmaceutiques et une concentration durable dans le sang.
Choi Jin Young
Jang Jeong-Soo
Jang Woo Jae
Kim Jae-Sun
Kum Do Seung
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Sk Chemicals Co. Ltd.
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