Amorphous atorvastatin calcium or pravastatin sodium hmg-coa...

Details Amorphous atorvastatin calcium or pravastatin sodium hmg-coa... Amorphous atorvastatin calcium or pravastatin sodium hmg-coa...

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) C07C 67/48 (2006.01) C07C 67/52 (2006.01) C07C 69/33 (2006.01)

Patent

CA 2479005

A process for the preparation of amorphous HMG-CoA reductase inhibitor and its hydrates thereof of desired particle size, which comprises: (a) dissolving the HMG-CoA reductase inhibitor in a hydroxylic solvent; (b) removing the solvent by freeze-drying.

Cette invention se rapporte à un procédé qui sert à préparer un inhibiteur de HMG-CoA réductase amorphe et ses hydrates avec taille souhaitée des particules et qui comprend : (a) à dissoudre cet inhibiteur de HMG-CoA réductase dans un solvant hydroxylique; et (b) à éliminer le solvant par lyophilisation.

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