C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/5377 (2006.01) A61K 31/54 (2006.01) A61K 47/38 (2006.01) A61P 1/04 (2006.01) A61P 1/06 (2006.01) A61P 1/18 (2006.01) A61P 11/00 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 27/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (
Patent
CA 2706536
[PROBLEMS] The object is to improve the absorbability of a heterocyclic compound including s-triazine and a pyrimidine derivative in vitro. [MEANS FOR SOLVING PROBLEMS] Disclosed is, for example, an amorphous body of a heterocyclic compound as represented by the general formula (I) [wherein each of R's and others is as defined in the description] including s-triazine and a pyrimidine derivative, or a hydrate, a solvate or a pharmaceutically acceptable salt of the heterocyclic compound. Also disclosed is a process for producing the amorphous body. Further disclosed are: a solid dispersion comprising the amorphous body; and a medicinal preparation comprising the solid dispersion.
Cette invention vise à améliorer la capacité de résorption in vitro d'un composé hétérocyclique comprenant de la s-triazine et un dérivé de pyrimidine. A cet effet, l'invention porte, par exemple, sur une forme amorphe d'un composé hétérocyclique tel que représenté par la formule générale (A) [dans laquelle les R et autres sont chacun tels que définis dans la description] et comprenant de la s-triazine et un dérivé de pyrimidine, ou un hydrate, un solvate ou un sel pharmaceutiquement acceptable du composé hétérocyclique. L'invention porte également sur un procédé de fabrication de la forme amorphe. L'invention porte également sur une dispersion solide comprenant la forme amorphe ; et sur une préparation médicinale comprenant la dispersion solide.
Ishihara Nobuhiro
Sugama Tadaaki
Takahashi Masayuki
Tanaka Yoshiharu
Watanabe Tetsuo
Marks & Clerk
Zenyaku Kogyo Kabushikikaisha
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