Amorphous substance of tricyclic triazolobenzazepine derivative

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 9/14 (2006.01) A61K 31/55 (2006.01) A61K 47/38 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2471651

Disclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8- dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes for producing 2-(1-isopropoxycarbonyloxy- 2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5- c][1]benzazepine, which has been rendered amorphous, and a pharmaceutical composition comprising the same.

L'invention porte sur 2-(1-isopropoxycabonyloxy-2-méthylpropyl)-7,8-diméthoxy-4(5H), 10-dioxo-2H-1, 2, 3-triazolo[4,5-c] [1]benzazépine amorphe dont l'absorbabilité et la solubilité sont améliorées. L'invention porte également sur une composition médicinale contenant le composé. L'invention porte, en outre, sur des procédés de production de 2-(1-isopropoxycabonyloxy-2-méthylpropyl)-7,8-diméthoxy-4(5H), 10-dioxo-2H-1, 2, 3-triazolo[4,5-c] [1]benzazépine amorphe et d'une composition médicinale contenant le composé.

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