Ampa antagonists and a method of treatment therewith

Details Ampa antagonists and a method of treatment therewith Ampa antagonists and a method of treatment therewith

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2161783

The present patent application discloses compounds having the formula Image or a pharmaceutically acceptable salt thereof wherein R1 is hydrogen, alkyl or benzyl; X is O or NOR2, wherein R2 is hydrogen, alkyl or benzyl; Y is N-R4 wherein R4 is hydrogen, OH or alkyl; n is 0 or 1; R6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting or halogen, CF3, NO2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders for example.

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