Ampa receptor antagonists and aldose reductase inhibitors...

Details Ampa receptor antagonists and aldose reductase inhibitors... Ampa receptor antagonists and aldose reductase inhibitors...

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/499 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2690086

The invention provides methods for treating and/or preventing neuropathic pain by administering to patients therapeutically effective amounts of AMPA receptor antagonists and aldose reductase inhibitors. The neuropathic pain may be diabetic neuropathy. The invention also provides kits, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists and aldose reductase inhibitors. The AMPA receptor antagonists may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one. The aldose reductase inhibitor may be, for example, ranirestat.

L'invention concerne des méthodes de traitement et/ou de prévention de la douleur neuropathique par administration, à des patients, de quantités thérapeutiquement efficaces d'anatagonistes des récepteurs AMPA et d'inhibiteurs d'aldose réductase. La douleur neuropathique peut être la neurophatie diabétique. L'invention concerne également des trousses, ainsi que des compositions pharmaceutiques comprenant des quantités thérapeutiquement efficaces d'anatagonistes des récepteurs AMPA et d'inhibiteurs d'aldose réductase. L'antagoniste des récepteurs AMPA peut être, par exemple, la 3-(2-cyanophényl)-5-(2-pyridyl)-1-phényl-1,2-dihydropyridin-2-one. L'inhibiteur d'aldose réductase peut être, par exemple, le ranirestat.

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