Ampa receptor antagonists and zonisamide for neuropathic pain

Details Ampa receptor antagonists and zonisamide for neuropathic pain Ampa receptor antagonists and zonisamide for neuropathic pain

A - Human Necessities

61

K

A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2690087

The invention provides methods for treating and/or preventing neuropathic pain by administering to patients therapeutically effective amounts of AMPA receptor antagonists and zonisamide. The neuropathic pain may be diabetic neuropathy. The invention also provides kits, and pharmaceutical compositions comprising therapeutically effective amounts of AMPA receptor antagonists and zonisamide. The AMPA receptor antagonist may be, for example, 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-- hydropyridin-2-one.

L'invention concerne des méthodes de traitement et/ou de prévention de la douleur neuropathique par administration de quantités thérapeutiquement efficaces d'antagonistes des récepteurs AMPA et de zonisamide. La douleur neuropathique peut être une neuropathie diabétique. L'invention concerne également des trousses, ainsi que des compositions pharmaceutiques comprenant des quantités thérapeutiquement efficaces d'antagonistes des récepteurs AMPA et de zonisamide. L'antagoniste des récepteurs AMPA peut être, par exemple, la 3-(2-cyanophényl)-5-(2-pyridyl)-1-phényl-1,2-dihydropyridin-2-one.

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