C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61P 31/04 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2414355
The invention concerns peptides containing or consisting of an antibiotic peptide by (i) modification of cysteine residues so that said peptide is devoid of disulphide bond, (ii) substitution of 1 to 18 and preferably of 1 to 5 amino acids, and/or permutation of at least a pair of amino acids, said substitutions and/or permutations being such that said peptide has an amphipathic character. The invention also concerns a compound formed by at least one of said peptide directly or indirectly bound to at least an active substance.
La présente invention a pour objet des peptides contenant ou constitués par un dérivé d'un peptide antibiotique par (i) modification des résidus cystéines de façon à ce que ledit peptide soit dépourvu de pont disulfure, (ii) substitution de 1 à 18 et de préférence de 1 à 6 acides aminés, et/ou permutation d'au moins une paire d'acides aminés, lesdites substitutions et/ou permutations étant telles que ledit peptide présente un caractère amphipathique. L'invention concerne aussi un composé formé d'au moins un desdits peptides lié directement ou indirectement à au moins une substance active.
Drin Guillaume
Gomar Jerome
Rees Anthony R.
Temsamani Jamal
Gowling Lafleur Henderson Llp
Synt:em S.a.
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