Amphipathic peptides

Details Amphipathic peptides Amphipathic peptides

C - Chemistry, Metallurgy

07

K

167/103.8

C07K 7/08 (2006.01) C07K 14/775 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1258229

ABSTRACT There are disclosed peptides capable of forming an amphipathic helix which contain the sequence A1-B1-B2-C1-D-B3-B4-A2-C2-B5-B6 -A3-C3-B7-C4-A4-B8-B9 wherein A1, A2, A3 and A4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof; B1, B2, B3, B4, B5, B6, B7, B8 and B9 are independently tryptophan, phenylalanine, alanine, leucine, tyrosine, isoleucine, valine or ?-naphthylalanine, or homologues or analogues thereof; C1, C2, C3 and C4 are independently lysine or arginine, and D is serine, threonine, alanine, glycine, histidine, or homologues or analogues thereof; provided that, when A1 and A2 are aspartic acid, A3 and A4 are glutamic acid, B2 and B9 are leucine, B3 and B7 are phenylalanine, B4 is tyrosine, B5 is valine, B6, B8, and D are alanine, and C1, C2, C3 and C4 are lysine, B1 is not tryptopohan. There are also disclosed compositions containing such peptides and as well the use of the novel peptides in the formation of substitute high density lipoproteins useful in the treatment of atherosclerosis.

481497

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