C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 47/48 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2433606
The invention concerns a peptide capable of transferring a substance of interest bearing negative charges inside cells and/or inside cell nuclei, characterised in that said peptide corresponds to the following formula: (RLLR)¿p?(L)¿n?(R)¿n?, wherein: L represents leucine, R represents arginine, p is an integer ranging between 2 and 4, n is 1 or 2. The invention also concerns a composition comprising said peptide and a substance of interest, more particularly a nucleic acid molecule.
La présente invention concerne un peptide capable de transférer une substance d'intérêt portant des charges négatives à l'intérieur des cellules et/ou à l'intérieur du noyau des cellules, caractérisé en ce que ledit peptide répond à la formule suivante: (RLLR)p(L)n(R)n, dans laquelle: L représente la leucine, R représente l'arginine, p est un nombre entier compris entre 2 et 4, n est 1 ou 2. L'invention concerne aussi une composition comprenant ledit peptide et une substance d'intérêt plus particulièrement une molécule d'acide nucléique.
Clair Philippe
Temsamani Jamal
Gowling Lafleur Henderson Llp
Synt:em
LandOfFree
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