Amphiphile nucleosidphosphatanaloga

Details Amphiphile nucleosidphosphatanaloga Amphiphile nucleosidphosphatanaloga

C - Chemistry, Metallurgy

07

H

C07H 19/10 (2006.01) A61K 31/70 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2129986

The present invention relates to amphiphilic nucleosidephosphate analogues of Formula I (See formula I) wherein R1 stands for a hydroxyl-, amino-, acylated, or alkylized amino group or one substituted by polyoxyethylene, whose acyl- or alkyl rest is linear or branched, have 1 to 24 C-atoms and up to 2 double bonds, and which can be substituted by an aromatic radicals R2 stands for H, F, a 2-bromvinyl radical or a linear or branched C1-C24 alkyl radical; R3 and R4 are identical or different and stand for H, hydroxyl, halogen and azido; R5 is a nucleoside radical of Formula II (See formula II) that is connected through R8, R9, or R10 to the nucleotide of Formula I. R5 can also stand for OH. A procedure for producing these, and pharmaceutical means are also described.

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