Amphiphilic [5:1]- and [3:3]- hexakisadducts of fullerenes

Details Amphiphilic [5:1]- and [3:3]- hexakisadducts of fullerenes Amphiphilic [5:1]- and [3:3]- hexakisadducts of fullerenes

C - Chemistry, Metallurgy

01

B

C01B 31/02 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) A61P 39/06 (2006.01)

Patent

CA 2540195

Herein are disclosed substituted fullerenes, comprising a fullerene core (Cn), wherein n is an even integer greater than or equal to 60; 3 or 5 dihydrocarbylmalonate (>C(COOR1)(COOR2)) groups bonded to the fullerene core; and 1 or 3 polar extended malonate groups (>C(COOR3)(COOR4)) bonded to the fullerene core. The substituted fullerenes can form micelles, and can be used to ameliorate oxidative stress diseases.

L'invention concerne des fullerènes substitués, qui comprennent un noyau fullerène (Cn), dans lequel n est un nombre entier pair supérieur ou égal à 60 ; 3 ou 5 groupes dihydrocarbylmalonate (>C(COOR?1¿)(COOR?2¿)) liés au noyau fullerène ; et 1 ou 3 groupes malonate étendus polaires (>C(COOR?3¿)(COOR?4¿)) liés au noyau fullerène. Lesdits fullerènes substitués peuvent former des micelles, et peuvent servir à soulager les maladies associées au stress oxydatif.

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