Amphiphilic drug-oligomer conjugates with hydrolyzable...

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A61K 47/48 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 38/00 (2006.01) A61K 38/28 (2006.01) C07K 17/02 (2006.01)

Patent

CA 2377517

The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, and oleic acid can be orally administered.

La présente invention concerne de façon générale des conjugués oligomères de médicaments hydrolysables, des compositions pharmaceutiques contenant de tels conjugués, ainsi que des procédés de préparation et d'utilisation de ces conjugués et compositions pharmaceutiques. Par exemple, un conjugué d'insuline, le PEG, et l'acide oléique peuvent être administrés par voie orale.

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