Amphiphilic lipid nanoparticles for peptide and/or protein...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01) A61K 38/09 (2006.01)

Patent

CA 2431888

Lipid nanoparticles loaded with drugs, such as peptides or proteins, are herein described. A process for obtaining them as well as their use for the preparation of a pharmaceutical composition is also disclosed. According to a preferred embodiment, the drug is a LHRH analogue, more preferably a LHRH antagonist, and the lipid matrix comprises at least 70% w/w of monoglycerides.

La présente invention concerne des nanoparticules lipidiques chargées de médicaments, par exemple des peptides ou des protéines, un procédé permettant d'obtenir ces nanoparticules lipidiques, ainsi qu'un procédé permettant de les utiliser dans la préparation d'une composition pharmaceutique. Dans un mode de réalisation préféré, le médicament est un analogue de la LHRH, de préférence un antagoniste de la LHRH, et la matrice lipidique comprend au moins 70 % en poids de monoglycérides.

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