C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 9/51 (2006.01) A61K 31/715 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01) C08B 37/16 (2006.01)
Patent
CA 2406823
Soluble amphiphilic macrocycle analogues having lipophilic groups attached to one side of the units making up the macrocycle and hydrophilic groups attached to the other side. These amphiphilic macrocyclic derivatives have the ability to self-assemble in aqueous solvent forming micelles or vesicles and can be used as hosts for the solubilisation and/or stabilisation of various compounds. Embodiments of the present invention utilise macrocyclic oligosaccharides and preferably cyclodextrin as the macrocyclic derivatives to be modified.
Analogues macrocycliques amphiphiles solubles qui contiennent des groupes lipophiles attachés sur un côté des unités constituant le macrocycle et des groupes hydrophiliques attachés sur l'autre côté. Ces dérivés macrocycliques amphiphiles possèdent la capacité de s'auto-assembler dans un solvant aqueux, formant ainsi des micelles ou des vésicules, et peuvent être utilisés en tant qu'hôtes pour la solubilisation et/ou la stabilisation de divers composés. Dans des modes de réalisation de la présente invention, des oligosaccharides macrocycliques, de préférence de la cyclodextrine, sont utilisés en tant que dérivés macrocycliques à modifier.
Darcy Raphael
Penkler Lawrence John
Ravoo Bart Jan
Moffat & Co.
University College Dublin
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