Amphiphilic networks, implantable immunoisolatory devices,...

C - Chemistry – Metallurgy – 08 – F

Patent

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C08F 290/12 (2006.01) A61K 9/00 (2006.01) C08F 8/00 (2006.01) C08F 220/56 (2006.01) C08F 222/10 (2006.01) C08F 255/10 (2006.01) C08F 283/00 (2006.01)

Patent

CA 2389922

The present invention provides high mechanical strength amphiphilic polymer networks and implantable biological devices that are capable of encasing and, thus, immunoisolating biological material from the immunological response of a host individual. The present invention also provides methods for the formation of the amphiphilic networks and implantable biological devices. The present invention also provides a method for the treatment of type I diabetes mellitus comprising the steps of encasing a sufficient amount of islet of Langerhans cells within said biological device, wherein said biological device is capable of immunoisolating said encased islet cells upon implantation into an individual; implanting said biological device into a diabetic host individual; allowing said implanted biological device to remain implanted said diabetic individual for a time sufficient to normalize the blood glucose level in said diabetic individual.

L'invention concerne des réseaux polymères amphiphiles à haute résistance mécanique et des dispositifs biologiques implantables capables d'encapsuler et, par conséquent, d'immunoisoler du matériau biologique de la réponse immunologique d'un individu hôte. L'invention concerne également des procédés de formation des réseaux amphiphiles et dispositifs biologiques implantables. Elle concerne en outre un procédé de traitement du diabète sucré type I qui consiste à encapsuler une dose suffisante d'îlots de cellules de Langerhans à l'intérieur dudit dispositif biologique, lequel est capable d'immunoisoler lesdites cellules d'îlots encapsulées dès implantation chez une personne; à implanter ledit dispositif biologique chez une personne diabétique hôte; à permettre au dispositif biologique implanté de rester ainsi implanté pendant une durée suffisante pour normaliser le taux de glucose dans le sang de la personne diabétique concernée.

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