Amphiphilic peptide compositions and analogues thereof

Details Amphiphilic peptide compositions and analogues thereof Amphiphilic peptide compositions and analogues thereof

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 5/10 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2047317

ABSTRACT OF THE DISCLOSURE A process for inhibiting growth of a target cell comprising administering to a host or to a target cell or virus a biologically active peptide which includes one of the following basic structures; R1-R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R1-R21R2; R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R1-R1; or R1-R2-R1-R1-R2-R2-R1-R1-R2-R2-R1-R2-R2-R1-R1-R2-R2-R1, wherein R1 is a hydrophobic amino acid, and R2 is a basic hydrophilic or neutral hydrophilic amino acid. A preferred peptide is of the structural formula: (SEQ ID NO:3). Substitution and deletion analogues of this peptide can be prepared that have increased biological activity. Such peptides can be employed as pharmaceuticals.

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