Amphiphilic polyamine compounds

Details Amphiphilic polyamine compounds Amphiphilic polyamine compounds

C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 48/00 (2006.01) C07C 217/20 (2006.01) C07C 217/22 (2006.01) C07C 271/20 (2006.01) C07C 311/19 (2006.01) C07C 311/64 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2352279

Amphiphilic polyamidine compounds (I) and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds, wherein each of X1, X2, X3, X4, X5 and X6 is independently selected from the group consisting of amine protecting groups comprising a carboxyl group and capable of forming an amide bond; r is an integer from 0 to 5; n is an integer from 7 to 21; and each of t1, t2, t3 and t4 is independently an integer from 0 to 5.

L'invention concerne des composés de polyamidine amphiphiles et des dérivés de ceux-ci, présentant la propriété de promouvoir la transfection de polynucléotides et de polypeptides dans des cellules. L'invention concerne également les formulations comprenant lesdits composés.

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