Amphiphilic polymeric vesicles

Details Amphiphilic polymeric vesicles Amphiphilic polymeric vesicles

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 9/127 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2388344

Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also be used. The copolymers may be crosslinked to form nanocapsules. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules, such as membrane proteins, can be incorporated into the wall of the vesicles or nanocapsules.

L'invention concerne des vésicules produites à partir de copolymères amphiphiles. Ces copolymères peuvent être des copolymères ABA, tels que l'un de A et B est hydrophile et l'autre hydrophobe. On peut également utiliser des copolymères AB. Les copolymères peuvent être réticulés de façon à former des nanocapsules. On peut réaliser la réticulation par de nombreux procédés, notamment par polymérisation de bout en bout de copolymères ayant des groupes insaturés terminaux. On peut incorporer, dans la paroi des vésicules ou nanocapsules, des molécules telles que des protéines membranaires.

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