Amphiphilic polymers and polypeptide conjugates comprising same

Details Amphiphilic polymers and polypeptide conjugates comprising same Amphiphilic polymers and polypeptide conjugates comprising same

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2394928

Proteins and/or peptides, such as luminal cholecystokinin releasing factor (LCRF), are conjugated with amphiphilic oligomers and polymers. Such conjugates may modulate the pharmacokinetic profile of the proteins and/or peptides, thereby improving their clinical utility. Such conjugates may also stabilize and deliver the proteins and/or peptides, such as LCRF, to receptors in the gut without absorption into the bloodstream.

Des protéines et/ou des peptides, tel qu'un facteur de terminaison de cholécystokinine luminal (LCRF), sont mélangés avec des oligomères et des polymères amphiphiles. Ces conjugués peuvent moduler le profil pharmacocinétique des protéines et/ou des peptides, améliorant ainsi leur utilité clinique. Ces conjugués peuvent également stabiliser les protéines et/ou les peptides, tels que les LCRF, et les administrer à des récepteurs situés dans l'intestin sans être absorbés dans le sang.

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