Amphoteric microgels for the delivery of compounds to cells

Details Amphoteric microgels for the delivery of compounds to cells Amphoteric microgels for the delivery of compounds to cells

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 31/06 (2006.01) A61P 31/18 (2006.01) A61P 33/06 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C08J 3/075 (2006.01) C08J 3/24 (2006.01) C08L 33/24 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2627903

The present disclosure relates to methods for delivering a compound to a cell comprising entrapping the compound in an amphoteric microgel wherein the microgel changes size or charge in response to environmental stimuli to entrap or release the compound, and delivering the amphoteric microgel to the cell. The disclosure further relates to a vaccine composition comprising the amphoteric microgel, and a vaccine adjuvant comprising an amphoteric microgel. The disclosure also relates to the use of a vaccine composition comprising the amphoteric microgel to deliver an antigen to an immune system cell and a use of an amphoteric microgel as an adjuvant.

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