Amphotericin b/cholesterol sulfate composition and method

Details Amphotericin b/cholesterol sulfate composition and method Amphotericin b/cholesterol sulfate composition and method

A - Human Necessities

61

K

167/185

A61K 47/28 (2006.01) A61K 9/51 (2006.01)

Patent

CA 1336890

An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.

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