Amphotericin b composition with enhanced antifungal activity

A - Human Necessities – 61 – K

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A61K 31/08 (2006.01) A61K 31/185 (2006.01) A61K 31/70 (2006.01) A61K 47/10 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2123780

Fungal infections are treated by administering a combination of: (a) amphotericin B, and (b) a glycerol ether selected from the group consisting of (i) HOCH2CHOHCH2OR, (ii) HOCH2CH(OR1)CH2OH, and (iii) combinations thereof, wherein R and R1 are independently selected from the group consisting of C8-C18 alkyl and C8-C18 alkenyl. The glycerol ether acts syn- ergistically to reduce the minimum inhibitory concentration of amphotericin B. The combination is particularly effective against Cryptococcus and Candida species.

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