Ampk-related serine/threonine kinase, designated snark

Details Ampk-related serine/threonine kinase, designated snark Ampk-related serine/threonine kinase, designated snark

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/45 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/63 (2006.01) G01N 33/543 (2006.01) G01N 33/573 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2340783

The cloning and function of a new AMPK-related kinase, designated SHARK, are described. The kinase SNARK is involved in the stress response tca glucose deprivation. Provided are the rodent and human genes encoding SHARK, and the SHARK protein and useful fragments, in isolated form. Also provided are SHARK expression systems and assays useful to identify SHARK substrates and SHARK activity modulators, and antibodies useful as SHARK modulators for instance in therapeutic applications to modulate the metabolism of glucose.

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