C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C07K 16/18 (2006.01) C12N 15/54 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2417802
The cloning and function of a new AMPK-related kinase, designated SNARK, are described. The kinase SNARK is involved in the stress response to glucose deprivation. Provided are the rodent and human genes encoding SNARK, and the SNARK protein and useful fragments, in isolated form. Also provided are SNARK expression systems and assays useful to identify SNARK substrates and SNARK activity modulators, and antibodies useful as SNARK modulators for instance in therapeutic applications to modulate the metabolism of glucose.
La présente invention concerne le clonage et le fonctionnement d'une nouvelle kinase apparentée à AMPK, appelée SNARK. La kinase SNARK est impliquée dans la réaction de stress produite par la privation de glucose. Cette invention concerne les gènes de rongeurs et d'humain codant SNARK, ainsi que la protéine SNARK et ses fragments utiles, sous une forme isolée ; des systèmes d'expression SNARK et des dosages utiles pour identifier des substrats SNARK et des modulateurs de l'activité SNARK ainsi que des anticorps utiles en tant que modulateurs SNARK, par exemple dans des applications thérapeutiques permettant de moduler le métabolisme du glucose.
Drucker Daniel J.
Lefebvre Diana L.
Rosen Cheryl F.
1149336 Ontario Inc.
Gastle And Associates
LandOfFree
Ampk-related serine/threonine kinase, designated snark does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ampk-related serine/threonine kinase, designated snark, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ampk-related serine/threonine kinase, designated snark will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1940284