Amplification of folate-mediated targeting to tumor cells...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01) A61K 31/519 (2006.01) A61K 47/48 (2006.01) A61K 51/06 (2006.01) A61P 35/00 (2006.01) C08B 11/08 (2006.01) C08B 11/20 (2006.01) C08B 37/02 (2006.01) C08B 37/08 (2006.01) C08F 120/56 (2006.01) C08F 220/58 (2006.01) C08F 251/00 (2006.01) C08F 251/02 (2006.01) C08G 65/329 (2006.01) C08G 65/34 (2006.01) C08G 69/36 (2006.01) C08G 71/04 (2006.01)

Patent

CA 2372841

The invention relates to the delivery of drug, peptide and protein pharmaceuticals using the folate-mediated uptake system. More particularly the invention relates to the amplification of drug/pharmaceutical delivery with the folate uptake system using a folate-polymer complex. The invention also relates to processes for preparing the complexes, pharmaceutical compositions containing same, methods of treatment involving the complexes and uses of the complexes in the manufacture of medicaments.

L'invention concerne l'administration de médicaments, de produits pharmaceutiques à base de peptides et de protéines à l'aide du système d'absorption induit par les folates. Plus particulièrement, l'invention a pour objet l'amplification de l'administration de médicaments/produits pharmaceutiques, le système d'absorption des folates utilisant un complexe folate-polymère. L'invention a également pour objet des procédés de préparation des complexes, des compositions pharmaceutiques à base de ces derniers, des procédés de traitement impliquant les complexes et l'utilisation de ces complexes dans la fabrication de médicaments.

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