Amplification of folate-mediated targeting to tumor cells...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01) A61K 31/519 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C08B 11/08 (2006.01) C08B 37/02 (2006.01) C08B 37/08 (2006.01) C08F 120/56 (2006.01) C08G 65/34 (2006.01) C08G 69/36 (2006.01) C08G 71/04 (2006.01) C08H 1/06 (2006.01)

Patent

CA 2372834

The invention relates to the delivery of drug, peptide and protein pharmaceuticals using the folate-mediated uptake system. More particularly the invention relates to the amplification of drug/pharmaceutical delivery with the folate uptake system using a folate-nanoparticle complex. The invention also relates to processes for preparing the complexes, pharmaceutical compositions containing same, methods of treatment involving the complexes and uses of the complexes in the manufacture of medicaments.

La présente invention concerne l'apport de médicament, de substances pharmaceutiques de type peptidique ou protéique effectué à l'aide du système d'absorption à médiation folate. De manière plus spécifique cette invention porte sur l'amplification de l'apport de médicament/substance pharmaceutique au moyen du système d'absorption folate avec un complexe folate-nanoparticules. Cette invention concerne également des procédés de préparation des complexes, de compositions pharmaceutiques contenant ces derniers, des procédés de traitement dans lesquels on utilise les complexes et les utilisations desdits complexes dans la fabrication de médicaments.

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