C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2542660
The present invention regards amplification of a signal from a hybridization- based oligonucleotide assay. In some embodiments, a bead comprises an oligonucleotide hybridized to a labeled polynucleotide from a sample, and a signal generated from a complex thereof is amplified through labeled antibodies directed to a receptor for the label. In particular embodiments, the assay provides information on gene expression.
La présente invention concerne l'amplification d'un signal à partir d'un dosage oligonucléotidique à hybridation. Dans certains modes de réalisation, une bille comprend un oligonucléotide hybridé avec un polynucléotide marqué d'un échantillon, et un signal généré à partir du complexe obtenu est amplifié à l'aide d'anticorps marqués dirigés vers un récepteur de la marque. Dans des modes de réalisation particuliers, le dosage fournit des informations sur l'expression génique.
Juhlin Kenton Duane
Jump Mary Lynn
Naciff Jorge Manuel
Richardson Brian David
Tiesman Jay Patrick
Mbm Intellectual Property Law Llp
The Procter & Gamble Company
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