A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/185
A61K 31/71 (1985.01)
Patent
CA 1196283
ABSTRACT The antibacterial and antitumor activity of certain specific members of the groups of compounds known as phleomycin, bleomycin and tallysomycin are amplified by administration in association with caffeine, dimethylthiocyanine or pyronine Y. The invention makes the active compounds effective at very low concentrations thereby avoiding the deleterious side effects normally associated with these compounds. The active compounds according to the present invention which show particularly advantageous characteristics when amplified as described above are those in which the phleomycin, bleomycin or tallycomycin is in an amide form having a substituent amine group selected from the following:- Image
380736
Grigg Geoffrey W.
Lamberton John
Bereskin & Parr
Commonwealth Scientific And Industrial Research Organization
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